Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17300824 | 0.80 | HRH3 (0.35) | — | |
| SCHEMBL19633518 | 0.75 | CCNT1 (0.36) | CCNT1CDK9 | |
| SCHEMBL17300822 | 0.71 | HRH4 (0.42) | CCNT1CDK9 | |
| SCHEMBL17300795 | 0.71 | HRH3 (0.34) | — | |
| SCHEMBL19171139 | 0.70 | ROCK1 (0.36) | — | |
| SCHEMBL17300827 | 0.68 | EHMT2 (0.34) | — | |
| SCHEMBL19171138 | 0.67 | CCNT1 (0.42) | CCNT1CDK9 | |
| SCHEMBL17306714 | 0.67 | MCHR1 (0.38) | CCNT1CDK9 | |
| SCHEMBL15834081 | 0.66 | CCNT1 (0.41) | CCNT1CDK9 | |
| SCHEMBL15834577 | 0.66 | DNM2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604930-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2017-03-28 | — | — | US | disclosed |