DNM2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3428347	0.56	11/20
SCHEMBL10696199	0.46	11/20
SCHEMBL10356814	0.42	11/20
SCHEMBL2947094	0.90	10/20
SCHEMBL1194281	0.78	10/20
SCHEMBL2943404	0.68	10/20
SCHEMBL8543215	0.57	10/20
SCHEMBL933094	0.45	10/20
SCHEMBL932573	0.44	10/20
SCHEMBL7638429	0.43	10/20
SCHEMBL7121214	0.42	10/20
SCHEMBL9813347	0.40	10/20
SCHEMBL4869272	0.39	10/20
SCHEMBL1918558	0.37	10/20
SCHEMBL8886910	0.60	9/20
SCHEMBL5791298	0.58	9/20
SCHEMBL7712160	0.56	9/20
SCHEMBL403583	0.56	9/20
SCHEMBL1032562	0.56	9/20
SCHEMBL3298608	0.56	9/20

Clinical trials — most relevant to DNM2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Motor Function Efficacy of Pharmacological Treatments Targeting Energy Metabolism, in Parkinson's Patients	PHASE4	UNKNOWN
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
The Synapse Project	PHASE2	COMPLETED
Safety and Efficacy Study of Antisense Oligonucleotides in Duchenne Muscular Dystrophy	PHASE1/PHASE2	COMPLETED
Interleukin-2 Treatment for Wiskott-Aldrich Syndrome	PHASE1	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes (DYNAMMO T2D)	EARLY_PHASE1	COMPLETED
Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise	nan	COMPLETED
Skeletal Muscle Regeneration in Survivors of Critical Illness: How to Prevent Satellite Cell Failure?	nan	RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans	nan	COMPLETED
Hyperglycemia and Mitochondrial Function in The Endothelium of Humans	nan	COMPLETED
Genetic Variation in CLTCL1 and Whole-body Glucose Control	nan	COMPLETED
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Combined Effects of Statins and Exercise on Training Sensitive Health Markers	nan	COMPLETED
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING
Identification of New Biomarkers of Insulin Resistance	nan	ACTIVE_NOT_RECRUITING
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Role of Polymorphisms in the IL-1 Gene Cluster	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
MERC Proteins in Saliva and GCF in Periodontal Disease (ELISA Study)	nan	COMPLETED
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Natural History Evaluation of Charcot Marie Tooth Disease (CMT) Types CMT1B, CMT2A, CMT4A, CMT4C, and Others	nan	RECRUITING
Identification of a New Gene Involved in Hereditary Lipodystrophy	nan	COMPLETED
Statins and the Urinary Proteome	nan	COMPLETED
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Neurophysiologic Biomarkers in Rett Syndrome	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a DNM2 binder may also engage these)

Protein	Name	Similarity
P39054	—	1.000	P39054 →
P39052	—	1.000	P39052 →
Q08877	—	1.000	Q08877 →
P39053	—	1.000	P39053 →
Q8BZ98	—	1.000	Q8BZ98 →
Q08DF4	—	1.000	Q08DF4 →
P21575	—	1.000	P21575 →
DNM1	Dynamin-1	1.000	landscape →
Q9UQ16	—	1.000	Q9UQ16 →
A6H7I5	—	1.000	A6H7I5 →
P39055	—	0.998	P39055 →
P79135	—	0.996	P79135 →
Q8WQC9	—	0.995	Q8WQC9 →
O35303	—	0.995	O35303 →
P27619	—	0.995	P27619 →
Q86T65	—	0.995	Q86T65 →
Q28379	—	0.995	Q28379 →
Q9N0Y2	—	0.994	Q9N0Y2 →
Q7SXN5	—	0.994	Q7SXN5 →
Q9N0Y3	—	0.993	Q9N0Y3 →
Q9BDI7	—	0.993	Q9BDI7 →
Q9WVP9	—	0.993	Q9WVP9 →
Q94CF0	—	0.993	Q94CF0 →
Q9NZN3	—	0.992	Q9NZN3 →
Q91197	—	0.992	Q91197 →
Q9FNX5	—	0.992	Q9FNX5 →
Q8R4Z9	—	0.992	Q8R4Z9 →
Q39821	—	0.992	Q39821 →
Q9H1H9	—	0.992	Q9H1H9 →
Q6DKF0	—	0.992	Q6DKF0 →