Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 0.68 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2403511 | 0.91 | CRHR1 (0.67) | CRHR1MAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL1868622 | 0.90 | CRHR1 (0.70) | CRHR1MAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL13117470 | 0.84 | CRHR1 (0.69) | CRHR1MAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL13139632 | 0.84 | CRHR1 (0.68) | CRHR1 | |
| SCHEMBL13117478 | 0.83 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL2403097 | 0.82 | CRHR1 (0.67) | CRHR1MAPTALDH1A1HPGDMAPK1 | |
| SCHEMBL2401221 | 0.82 | CRHR1 (0.74) | CRHR1 | |
| SCHEMBL2403821 | 0.82 | CRHR1 (0.66) | CRHR1 | |
| SCHEMBL2403009 | 0.82 | CRHR1 (0.66) | CRHR1 | |
| SCHEMBL2404350 | 0.81 | CRHR1 (0.63) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7947697-B1 | 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d] pyrazolo[1,5-a]pyrimidine methanesulfonate as a CRF antagonist | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-05-24 | — | — | US | disclosed |
| US-7947697-B1 | 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d] pyrazolo[1,5-a]pyrimidine methanesulfonate as a CRF antagonist | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-05-24 | — | — | US | disclosed |
| US-7947697-B1 | 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d] pyrazolo[1,5-a]pyrimidine methanesulfonate as a CRF antagonist | ONO PHARMACEUTICAL CO., LTD. (JP) | 2011-05-24 | — | — | US | disclosed |
| EP-1637531-B1 | METHANESULFONIC ACID SALT OF PYRAZOLOPYRIMIDINE COMPOUND, CRYSTAL THEREOF, AND PROCESS FOR PRODUCING THE SAME | ONO PHARMACEUTICAL CO (JP) | 2010-08-25 | — | — | EP | disclosed |
| EP-1637531-B1 | METHANESULFONIC ACID SALT OF PYRAZOLOPYRIMIDINE COMPOUND, CRYSTAL THEREOF, AND PROCESS FOR PRODUCING THE SAME | ONO PHARMACEUTICAL CO (JP) | 2010-08-25 | — | — | EP | disclosed |
| EP-1637531-A1 | METHANESULFONIC ACID SALT OF PYRAZOLOPYRIMIDINE COMPOUND, CRYSTAL THEREOF, AND PROCESS FOR PRODUCING THE SAME | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |