Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1702078 | 0.88 | LMNA (0.42) | LMNAMAPTATMPOLBALDH1A1 | |
| SCHEMBL1700651 | 0.88 | LMNA (0.47) | LMNAMAPTATMPOLBALDH1A1 | |
| SCHEMBL1700459 | 0.84 | LMNA (0.45) | LMNAMAPTATMPOLBALDH1A1 | |
| SCHEMBL1700462 | 0.84 | LMNA (0.45) | LMNAMAPTATMPOLBALDH1A1 | |
| SCHEMBL1700056 | 0.81 | LMNA (0.51) | LMNAMAPTATMPOLBALDH1A1 | |
| SCHEMBL1700025 | 0.80 | LMNA (0.48) | LMNAMAPTPOLBALDH1A1BRD4 | |
| SCHEMBL30467937 | 0.80 | LMNA (0.48) | LMNAMAPTPOLBALDH1A1BRD4 | |
| SCHEMBL1861017 | 0.79 | LMNA (0.39) | LMNAMAPTATMPOLBALDH1A1 | |
| SCHEMBL25416611 | 0.78 | LMNA (0.49) | LMNAMAPTPOLBALDH1A1BRD4 | |
| SCHEMBL1869625 | 0.78 | LMNA (0.48) | LMNAMAPTATMPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435432-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010138588-A9 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2010138588-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |