Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | PPP3CA | Q08209 | 1/20 | 0.33 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1001001 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL4925 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL738868 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL9176590 | 1.00 | CA4 (1.00) | CA4CYP3A4TSHRGSK3BGPR39 | |
| Hydrochloric Acid SCHEMBL187463 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL640769 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL2782873 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL1836319 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL6334241 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL1767198 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2607381-B1 | FUNCTIONALIZED ELASTOMER, RUBBER COMPOSITION AND TIRE | GOODYEAR TIRE & RUBBER (US) | 2018-01-24 | — | — | EP | disclosed |
| US-9416211-B2 | Rubber composition and pneumatic tire | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2016-08-16 | — | — | US | disclosed |
| EP-2735587-B1 | Self-healing rubber composition and tire or article of manufacture | GOODYEAR TIRE & RUBBER (US) | 2016-07-20 | — | — | EP | disclosed |
| US-20160083494-A1 | RUBBER COMPOSITION AND PNEUMATIC TIRE | GOODYEAR TIRE & RUBBER COMPANY, THE | 2016-03-24 | — | — | US | disclosed |
| US-9243135-B2 | Rubber composition and runflat tire | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2016-01-26 | — | — | US | disclosed |
| US-9163101-B2 | Rubber composition and pneumatic tire | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2015-10-20 | — | — | US | disclosed |
| US-20150232649-A1 | RUBBER COMPOSITION AND RUNFLAT TIRE | THE GOODYEAR TIRE & RUBBER COMPANY | 2015-08-20 | — | — | US | disclosed |
| US-9050856-B2 | Rubber composition and runflat tire | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2015-06-09 | — | — | US | disclosed |
| US-8962730-B2 | Self-healing rubber composition and tire | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2015-02-24 | — | — | US | disclosed |
| US-8859687-B2 | Functiontionalized elastomer | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 2014-10-14 | — | — | US | disclosed |
| CN-101445754-A | Additive for improving low-temperature startup of methanol diesel oil | SHANXI HUADUN INDUSTRY CO LTD (CN) | 2009-06-03 | — | — | CN | disclosed |
| EP-1395544-A4 | METHODS OF MAKING 21- 4'-(NITROOXYALKYL) BENZOATE CORTICOSTEROID DERIVATIVES AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | NICOX SA (FR) | 2009-05-27 | — | — | EP | disclosed |
| EP-1395544-A1 | METHODS OF MAKING 21- 4'-(NITROOXYALKYL) BENZOATE] CORTICOSTEROID DERIVATIVES AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | Scynexis Chemistry and Automation, Inc. (US) | 2004-03-10 | — | — | EP | disclosed |
| US-6696592-B2 | FORMING REDUCED SIDE EFFECTS DERIVATIVE | NICOX-S.A. (FR) | 2004-02-24 | — | — | US | disclosed |
| US-20030153545-A1 | Methods of making 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof | NICOX S.A. (FR) | 2003-08-14 | — | — | US | disclosed |
| WO-2002094942-A1 | METHOD OF PURIFYING POLYCYCLIC DYES | OPTIVA, INC. (US) | 2002-11-28 | — | — | WO | disclosed |
| WO-2002094758-A1 | METHODS OF MAKING 21-[4'-(NITROOXYALKYL) BENZOATE] CORTICOSTEROID DERIVATIVES AND INTERMEDIATES USEFUL IN THE SYNTHESIS THEREOF | NICOX S. A. (FR) | 2002-11-28 | — | — | WO | disclosed |
| US-4452983-A | N-(2-PIPERIDYLMETHYL)-2,2,2-TRIFLUOROETHOXY)-BENZAMIDE | RIKER LABORATORIES, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4390716-A | INTERMEDIATES FOR ANTIARRHYTHMIC BENZAMIDE COMPOUNDS | RIKER LABORATORIES, INC. (US) | 1983-06-28 | — | — | US | disclosed |
| US-4339587-A | ANTIARRHYTHMIA AGENTS | RIKER LABORATORIES, INC. (US) | 1982-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153545-A1 | Methods of making 21-[4'-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof | CYP11B1, CYP17A1, CYP21A2 | SLC6A2 3056/4885CA4 371/4885CYP3A4 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.