SCHEMBL1868077

SCHEMBL1868077

[2H]c1c([2H])c([2H])c(-c2c(Br)ccc3cc4cc5ccccc5cc4cc23)c([2H])c1[2H]

nearest known ligand 0.33

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.33
HIF1A Q16665 2/20 0.33
HSD17B10 Q99714 2/20 0.33
CYP1B1 Q16678 1/20 0.33
CYP2A6 P11509 1/20 0.32
CYP3A4 P08684 1/20 0.32
ALOX15 P16050 1/20 0.32
CASP1 P29466 1/20 0.32
CASP7 P55210 1/20 0.32
HBB P68871 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27729531 0.82 ESR1 (0.43) ALDH1A1HIF1AHSD17B10CYP1B1CYP2A6
SCHEMBL28970846 0.80 ESR1 (0.44) ALDH1A1HIF1AHSD17B10CYP1B1CYP2A6
SCHEMBL28034253 0.79 ESR1 (0.41) ALDH1A1HIF1AHSD17B10CYP1B1CYP2A6
SCHEMBL11992419 0.74 ESR1 (0.37) ALDH1A1HIF1AHSD17B10CYP1B1CYP2A6
SCHEMBL11971451 0.73 ALDH1A1 (0.39) ALDH1A1HIF1AHSD17B10CYP1B1CYP3A4
SCHEMBL1869357 0.72 ESR1 (0.45) ALDH1A1HIF1AHSD17B10CYP3A4ALOX15
SCHEMBL11971436 0.71 SOS1 (0.38) ALDH1A1HIF1AHSD17B10CYP1B1CASP1
SCHEMBL5012382 0.70 ALDH1A1 (0.44) ALDH1A1HIF1AHSD17B10CYP1B1CYP2A6
SCHEMBL5013845 0.70 ALDH1A1 (0.44) ALDH1A1HIF1AHSD17B10CYP1B1CYP2A6
SCHEMBL5010132 0.70 ALDH1A1 (0.44) ALDH1A1HIF1AHSD17B10CYP1B1CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9517977-B2 Materials for electronic devices MERCK PATENT GMBH (DE) 2016-12-13 US disclosed
US-20120211701-A1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2012-08-23 US disclosed
WO-2011050888-A1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2011-05-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120211701-A1 MATERIALS FOR ELECTRONIC DEVICES XPOT, ETV6, ERCC1 ALDH1A1 106/4885HIF1A 4048/4885HSD17B10 3009/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.