Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 19/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 18/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868080 | 1.00 | SLC6A4 (0.38) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL5506058 | 0.88 | SLC6A4 (0.38) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL5506061 | 0.88 | SLC6A4 (0.38) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL6526760 | 0.86 | SLC6A4 (0.37) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL181909 | 0.81 | SLC6A4 (0.42) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL1033810 | 0.81 | SLC6A4 (0.42) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL65492 | 0.81 | SLC6A4 (0.42) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| Hydrochloric Acid SCHEMBL25408690 | 0.79 | SLC6A4 (0.41) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL1863664 | 0.79 | SLC6A4 (0.40) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 | |
| SCHEMBL2707862 | 0.79 | SLC6A4 (0.40) | SLC6A4SLC6A2KCNH2SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435432-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | Abbott Laboratories (US) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010138588-A9 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2011-05-05 | — | — | WO | disclosed |
| WO-2010138588-A2 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |