Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18682431 | 0.78 | RECQL (0.39) | PRMT5WDR77GPR119PIK3CDRECQL | |
| SCHEMBL18682471 | 0.78 | PIK3CD (0.43) | PRMT5WDR77GPR119PIK3CDPIK3CA | |
| SCHEMBL7710397 | 0.76 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15134922 | 0.76 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL18682803 | 0.68 | GPR119 (0.43) | PRMT5WDR77GPR119PIK3CD | |
| SCHEMBL29770656 | 0.68 | GPR119 (0.45) | PRMT5WDR77GPR119PIK3CD | |
| SCHEMBL29770662 | 0.68 | GPR119 (0.45) | PRMT5WDR77GPR119PIK3CD | |
| SCHEMBL16175096 | 0.67 | TMEM97 (0.36) | GRM5GRM1PIK3CA | |
| SCHEMBL2595717 | 0.67 | PDE10A (0.51) | GPR119PIK3CA | |
| SCHEMBL15000904 | 0.67 | GPR119 (0.58) | PRMT5WDR77GPR119PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2986616-B1 | TRICYCLIC TRIAZOLIC COMPOUNDS AS SIGMA RECEPTORS LIGANS | ESTEVE LABOR DR (ES) | 2017-03-29 | — | — | EP | disclosed |