Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 14/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.35 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27945123 | 0.90 | AAK1 (0.50) | AAK1PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL253236 | 0.90 | AAK1 (0.50) | AAK1PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL244454 | 0.85 | AAK1 (0.48) | AAK1PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18682936 | 0.85 | AAK1 (0.45) | AAK1PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21677166 | 0.85 | AAK1 (0.45) | AAK1PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15187901 | 0.84 | AAK1 (0.47) | AAK1PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15839647 | 0.84 | AAK1 (0.47) | AAK1NPC1RAB9ASMN1; SMN2RECQL | |
| SCHEMBL362462 | 0.84 | AAK1 (0.47) | AAK1PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15187905 | 0.83 | AAK1 (0.47) | AAK1PTGDR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16461442 | 0.82 | AAK1 (0.46) | AAK1PTGDR2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353163-B1 | 2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-05 | — | — | EP | disclosed |
| WO-2017050978-A1 | 2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-30 | — | — | WO | disclosed |