Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023788 | 0.86 | PIN1 (0.40) | TAAR1LMNAPOLBNPSR1L3MBTL1 | |
| SCHEMBL6773107 | 0.81 | POLB (0.47) | TAAR1LMNAPOLBNPSR1PIN1 | |
| SCHEMBL17857575 | 0.81 | POLB (0.47) | TAAR1LMNAPOLBNPSR1PIN1 | |
| SCHEMBL18517369 | 0.80 | TAAR1 (0.41) | TAAR1LMNAPOLBNPSR1L3MBTL1 | |
| SCHEMBL15994532 | 0.77 | PIN1 (0.42) | POLBPIN1ALDH1A1MMP8NPC1 | |
| SCHEMBL31059194 | 0.77 | PIN1 (0.42) | POLBPIN1ALDH1A1MMP8NPC1 | |
| SCHEMBL23377841 | 0.77 | MAPT (0.45) | LMNANPSR1MAPK1MAPTNPC1 | |
| SCHEMBL23377838 | 0.77 | MAPT (0.45) | LMNANPSR1MAPK1MAPTNPC1 | |
| Hydrochloric Acid SCHEMBL5967467 | 0.76 | PIN1 (0.45) | POLBPIN1ALDH1A1MMP8NPC1 | |
| Hydrochloric Acid SCHEMBL28557077 | 0.75 | MAPT (0.44) | LMNANPSR1MAPK1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353163-B1 | 2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-05 | — | — | EP | disclosed |
| WO-2017050978-A1 | 2,3,4,5-TETRAHYDROPYRIDIN-6-AMINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2017-03-30 | — | — | WO | disclosed |