SCHEMBL1868443

SCHEMBL1868443

C1=CCC2=c3ccccc3=CNC2=C1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6387013 0.71
SCHEMBL17097355 0.69
SCHEMBL6307532 0.68
SCHEMBL28237716 0.68
SCHEMBL27352675 0.66
SCHEMBL28456768 0.64
SCHEMBL11786534 0.64
SCHEMBL11493960 0.64
SCHEMBL10888763 0.64
SCHEMBL4782477 0.63

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005023253-A1 USE OF PDE4 INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS ALTANA PHARMA AG (DE) 2005-03-17 WO claimed
EP-0610283-A1 DNA BIS-INTERCALATORS ISIS INNOVATION LIMITED (GB) 1994-08-17 EP claimed
WO-1993008165-A1 DNA BIS-INTERCALATORS ISIS INNOVATION LIMITED (GB) 1993-04-29 WO claimed
US-11773064-B2 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2023-10-03 US disclosed
US-20200407314-A1 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L (IT) 2020-12-31 US disclosed
US-10800739-B2 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2020-10-13 US disclosed
EP-2912032-B1 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2020-05-27 EP disclosed
US-20190330151-A1 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L (IT) 2019-10-31 US disclosed
EP-2454236-B1 3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2019-09-04 EP disclosed
US-10385018-B2 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2019-08-20 US disclosed
EP-3429563-A1 COMPOSITIONS AND METHODS FOR TREATING COMPULSIVE-LIKE BEHAVIOR IN A SUBJECT University of the Sciences in Philadelphia (US) 2019-01-23 EP disclosed
EP-2454236-A1 3-OXO-2, 3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS Nerviano Medical Sciences S.r.l. (IT) 2012-05-23 EP disclosed
WO-2011006794-A9 3-OXO-2, 3-DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES AS PARP INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-05 WO disclosed
WO-2011006803-A9 3-0X0-2, 3, -DIHYDRO-1H-ISOINDOLE-4-CARBOXAMIDES WITH SELECTIVE PARP-1 INHIBITION NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-05 WO disclosed
EP-1147089-A1 PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 2001-10-24 EP disclosed
WO-2000042020-A1 PHENYLPHENANTHRIDINES WITH PDE-IV INHIBITING ACTIVITY BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 2000-07-20 WO disclosed
EP-0889886-A1 NOVEL PHENANTHRIDINES SUBSTITUTED IN THE 6 POSITION Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1999-01-13 EP disclosed
WO-1997035854-A1 NOVEL PHENANTHRIDINES SUBSTITUTED IN THE 6 POSITION BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1997-10-02 WO disclosed
EP-0610283-A1 DNA BIS-INTERCALATORS ISIS INNOVATION LIMITED (GB) 1994-08-17 EP disclosed
WO-1993008165-A1 DNA BIS-INTERCALATORS ISIS INNOVATION LIMITED (GB) 1993-04-29 WO disclosed