Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2122405 | 0.92 | CYP2C9 (0.37) | KMT2ANR3C2SYKGAALMNA | |
| SCHEMBL2123123 | 0.89 | NR3C2 (0.40) | KMT2ANR3C2SYKPARP1RXFP1 | |
| SCHEMBL2123293 | 0.89 | CSNK2A1 (0.42) | CSNK2A1KMT2ANR3C2SYKALDH1A1 | |
| SCHEMBL2124835 | 0.85 | NR3C2 (0.39) | KMT2ANR3C2SYKGAAALDH1A1 | |
| SCHEMBL2125808 | 0.85 | ALDH1A1 (0.38) | CSNK2A1KMT2ANR3C2GAALMNA | |
| SCHEMBL18686162 | 0.84 | KMT2A (0.39) | KMT2ANR3C2GAALMNAALDH1A1 | |
| SCHEMBL2125865 | 0.84 | NR3C2 (0.39) | KMT2ANR3C2SYKGAAALDH1A1 | |
| SCHEMBL2124521 | 0.81 | MAPT (0.41) | KMT2ANR3C2SYKGAAALDH1A1 | |
| SCHEMBL2123296 | 0.81 | SYK (0.43) | KMT2ANR3C2SYKGAAALDH1A1 | |
| SCHEMBL2124567 | 0.80 | SYK (0.42) | KMT2ANR3C2SYKGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443123-B1 | SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | RIGEL PHARMACEUTICALS INC (US) | 2017-04-05 | — | — | EP | claimed |