Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL111558 | 0.94 | TDP1 (0.61) | TDP1ALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL397286 | 0.94 | TDP1 (0.61) | TDP1ALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL111557 | 0.94 | TDP1 (0.61) | TDP1ALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL30367352 | 0.94 | TDP1 (0.61) | TDP1ALDH1A1HPGDHSD17B10TSHR | |
| Benzyl Salicylate SCHEMBL28291087 | 0.88 | TDP1 (0.68) | TDP1ALDH1A1KDM4ETSHRL3MBTL1 | |
| SCHEMBL30853556 | 0.87 | HMGB1 (0.46) | TDP1ALDH1A1KDM4EHMGB1HSD17B10 | |
| SCHEMBL1868662 | 0.86 | ALDH1A1 (0.52) | TDP1ALDH1A1HPGDKDM4EHSD17B10 | |
| 2-Hydroxybenzoic Acid Hexyl Ester SCHEMBL29088839 | 0.86 | ALDH1A1 (0.63) | TDP1ALDH1A1KDM4ESMN1; SMN2HSD17B10 | |
| 2-Hydroxybenzoic Acid Hexyl Ester SCHEMBL29088840 | 0.86 | ALDH1A1 (0.63) | TDP1ALDH1A1KDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL29141613 | 0.84 | TDP1 (0.58) | TDP1ALDH1A1HPGDKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496682-A1 | DELIVERY PARTICLE | The Procter & Gamble Company (US) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011056935-A1 | DELIVERY PARTICLE | THE PROCTER & GAMBLE COMPANY (US) | 2011-05-12 | — | — | WO | disclosed |