Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.67 |
| ▸ | VEGFA | P15692 | 10/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL271286 | 0.91 | EGLN1 (0.67) | EGLN1VEGFALMNAPOLBSIGMAR1 | |
| SCHEMBL272116 | 0.88 | VEGFA (0.85) | EGLN1VEGFALMNAPOLBKMT2A | |
| SCHEMBL1873562 | 0.87 | VEGFA (0.68) | EGLN1VEGFALMNAPOLBKMT2A | |
| SCHEMBL1770292 | 0.87 | EGLN1 (0.67) | EGLN1VEGFALMNAPOLBSIGMAR1 | |
| SCHEMBL30963341 | 0.87 | EGLN1 (0.63) | EGLN1VEGFAPOLBKMT2AMAPT | |
| SCHEMBL1770457 | 0.87 | EGLN1 (0.63) | EGLN1VEGFAPOLBKMT2AMAPT | |
| SCHEMBL1870702 | 0.87 | EGLN1 (0.63) | EGLN1VEGFALMNAPOLBSIGMAR1 | |
| SCHEMBL1866840 | 0.87 | VEGFA (0.63) | EGLN1VEGFAPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL1770053 | 0.86 | EGLN1 (0.64) | EGLN1VEGFALMNAPOLBKMT2A | |
| SCHEMBL12667280 | 0.85 | EGLN1 (0.61) | EGLN1VEGFALMNAPOLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496236-A1 | PROLYL HYDROXYLASE INHIBITORS | Aerpio Therapeutics Inc. (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011057115-A1 | PROLYL HYDROXYLASE INHIBITORS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | claimed |