Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.63 |
| ▸ | VEGFA | P15692 | 7/20 | 0.63 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid Methyl Ester SCHEMBL27951076 | 0.92 | EGLN1 (0.54) | EGLN1VEGFAHTR6MAOBLMNA | |
| Tert-Butyl Formate SCHEMBL27937874 | 0.90 | EGLN1 (0.52) | EGLN1VEGFAHTR6MAOBLMNA | |
| Ethoxycarbonyl Group SCHEMBL27951052 | 0.90 | EGLN1 (0.52) | EGLN1VEGFAHTR6MAOBLMNA | |
| SCHEMBL24254260 | 0.87 | VEGFA (0.63) | EGLN1VEGFALMNAPOLBMAPT | |
| SCHEMBL271286 | 0.87 | EGLN1 (0.67) | EGLN1VEGFAHTR6LMNAPOLB | |
| SCHEMBL1868684 | 0.87 | EGLN1 (0.67) | EGLN1VEGFALMNAPOLBSMN1; SMN2 | |
| SCHEMBL17028831 | 0.87 | VEGFA (0.60) | EGLN1VEGFALMNASMN1; SMN2KMT2A | |
| SCHEMBL1870466 | 0.87 | VEGFA (0.60) | EGLN1VEGFAPOLBSMN1; SMN2CHRM3 | |
| SCHEMBL1770292 | 0.85 | EGLN1 (0.67) | EGLN1VEGFALMNAPOLBSMN1; SMN2 | |
| SCHEMBL27951075 | 0.83 | HTR6 (0.46) | EGLN1VEGFAHTR6MAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496236-A1 | PROLYL HYDROXYLASE INHIBITORS | Aerpio Therapeutics Inc. (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011057115-A1 | PROLYL HYDROXYLASE INHIBITORS | AKEBIA THERAPEUTICS INC. (US) | 2011-05-12 | — | — | WO | claimed |