Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 10/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.57 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | PDE1A | P54750 | 2/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868269 | 0.90 | ADORA1 (0.59) | ADORA1ADORA2AADORA2BCHRNB2CHRNA4 | |
| SCHEMBL1871255 | 0.88 | ADORA1 (0.46) | ADORA1ADORA2AADORA2BCHRNB2CHRNA4 | |
| SCHEMBL1871420 | 0.87 | ADORA1 (0.41) | ADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL1866236 | 0.86 | ADORA1 (0.41) | ADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL1875802 | 0.84 | ADORA1 (0.44) | ADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL1875306 | 0.83 | ADORA1 (0.56) | ADORA1ADORA2AADORA2BCHRNB2CHRNA4 | |
| SCHEMBL1868066 | 0.82 | ADORA1 (0.38) | ADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL1870705 | 0.82 | ADORA1 (0.42) | ADORA1ADORA2AADORA2BCHRNB2CHRNA4 | |
| SCHEMBL1869240 | 0.81 | ADORA1 (0.38) | ADORA1ADORA2AADORA2BADORA3 | |
| SCHEMBL1864786 | 0.81 | ADORA1 (0.39) | ADORA1ADORA2AADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499142-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | Advinus Therapeutics Limited (IN) | 2012-09-19 | — | — | EP | claimed |
| WO-2011055391-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-05-12 | — | — | WO | claimed |