Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MASP2 | O00187 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.40 |
| ▸ | KLK1 | P06870 | 3/20 | 0.39 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | FES | P07332 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | FER | P16591 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868891 | 1.00 | MASP2 (0.43) | MASP2KLKB1KLK1METAP2ABL1 | |
| SCHEMBL1872338 | 0.93 | MASP2 (0.44) | MASP2KLKB1KLK1METAP2ABL1 | |
| SCHEMBL1872344 | 0.93 | MASP2 (0.44) | MASP2KLKB1KLK1METAP2ABL1 | |
| SCHEMBL1869378 | 0.92 | KLKB1 (0.44) | MASP2KLKB1KLK1ABL1FLT3 | |
| SCHEMBL1886931 | 0.92 | KLKB1 (0.44) | MASP2KLKB1KLK1ABL1FLT3 | |
| SCHEMBL1869371 | 0.92 | KLKB1 (0.44) | MASP2KLKB1KLK1ABL1FLT3 | |
| SCHEMBL1868674 | 0.91 | MASP2 (0.42) | MASP2KLKB1KLK1ABL1FLT3 | |
| SCHEMBL1868678 | 0.91 | MASP2 (0.42) | MASP2KLKB1KLK1ABL1FLT3 | |
| SCHEMBL1866502 | 0.91 | MASP2 (0.43) | MASP2KLKB1KLK1METAP2ABL1 | |
| SCHEMBL1866499 | 0.91 | MASP2 (0.43) | MASP2KLKB1KLK1METAP2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011051672-A1 | AZAINDOLE DERIVATIVES | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | claimed |
| WO-2011051672-A1 | AZAINDOLE DERIVATIVES | VANTIA LIMITED (GB) | 2011-05-05 | — | — | WO | disclosed |