Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 13/20 | 0.87 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Losoxantrone SCHEMBL61319 | 0.93 | TOP2A (1.00) | TOP2AMEN1USP2LMNATP53 | |
| Losoxantrone SCHEMBL29360703 | 0.93 | TOP2A (1.00) | TOP2AMEN1USP2LMNATP53 | |
| Losoxantrone SCHEMBL6685621 | 0.92 | TOP2A (0.98) | TOP2AMEN1USP2LMNATP53 | |
| Losoxantrone SCHEMBL29409658 | 0.92 | TOP2A (0.98) | TOP2AMEN1USP2LMNATP53 | |
| SCHEMBL22877226 | 0.92 | TOP2A (0.87) | TOP2AMEN1USP2LMNATP53 | |
| Losoxantrone SCHEMBL5170 | 0.91 | TOP2A (0.96) | TOP2AMEN1USP2LMNATP53 | |
| Losoxantrone SCHEMBL27927741 | 0.91 | TOP2A (0.94) | TOP2AMEN1USP2LMNATP53 | |
| Losoxantrone SCHEMBL27975856 | 0.89 | TOP2A (0.88) | TOP2AMEN1USP2LMNATP53 | |
| SCHEMBL10800466 | 0.88 | TOP2A (0.90) | TOP2AMEN1USP2LMNATP53 | |
| Losoxantrone SCHEMBL28322423 | 0.87 | TOP2A (0.84) | TOP2AMEN1USP2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021007322-A1 | METHODS OF USING MODIFIED CYTOTOXINS TO TREAT CANCER | NORTHWESTERN UNIVERSITY (US) | 2021-01-14 | — | — | WO | disclosed |
| WO-2017053391-A1 | MODIFIED CYTOTOXINS AND THEIR THERAPEUTIC USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-30 | — | — | WO | disclosed |