Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 11/20 | 0.94 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | RECQL | P46063 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | NSD2 | O96028 | 2/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Losoxantrone SCHEMBL61319 | 0.97 | TOP2A (1.00) | TOP2AMEN1USP2LMNARECQL | |
| Losoxantrone SCHEMBL29360703 | 0.97 | TOP2A (1.00) | TOP2AMEN1USP2LMNARECQL | |
| Losoxantrone SCHEMBL6685621 | 0.96 | TOP2A (0.98) | TOP2AMEN1USP2LMNARECQL | |
| Losoxantrone SCHEMBL29409658 | 0.96 | TOP2A (0.98) | TOP2AMEN1USP2LMNARECQL | |
| Losoxantrone SCHEMBL5170 | 0.95 | TOP2A (0.96) | TOP2AMEN1USP2LMNARECQL | |
| SCHEMBL10800466 | 0.94 | TOP2A (0.90) | TOP2AMEN1USP2LMNARECQL | |
| Losoxantrone SCHEMBL27975856 | 0.93 | TOP2A (0.88) | TOP2AMEN1USP2LMNARECQL | |
| SCHEMBL22877226 | 0.91 | TOP2A (0.87) | TOP2AMEN1USP2LMNARECQL | |
| SCHEMBL18689529 | 0.91 | TOP2A (0.87) | TOP2AMEN1USP2LMNARECQL | |
| SCHEMBL10805434 | 0.90 | TOP2A (0.86) | TOP2AMEN1USP2LMNARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102892779-B | Neuregulin antagonist and the purposes in treatment cancer thereof | 基因泰克公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-102580084-B | The fixed dosage of HER antibody is administered | 健泰科生物技术公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-106148547-A | Diagnostic method and composition for treatment of cancer | 霍夫曼-拉罗奇有限公司 | 2016-11-23 | — | — | CN | disclosed |
| CN-104011078-B | Anti-poly-ubiquitin antibody and using method | 健泰科生物技术公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-103596983-B | Anti-FGFR4 antibody and using method | 霍夫曼-拉罗奇有限公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-102770158-B | Antibody formulations | 霍夫曼-拉罗奇有限公司 | 2016-10-19 | — | — | CN | disclosed |
| CN-103554263-B | Apoptotic anti-IgE antibodies in conjunction with the IgE that film combines | 健泰科生物技术公司 | 2016-09-28 | — | — | CN | disclosed |
| CN-103030696-B | Antibody and immune conjugate and application thereof | 健泰科生物技术公司 | 2016-09-28 | — | — | CN | disclosed |
| CN-103649117-B | Fc variant and the method for generation thereof | 霍夫曼-拉罗奇有限公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-103396485-B | The method and composition of targeting polyubiquitin | 健泰科生物技术公司 | 2016-08-10 | — | — | CN | disclosed |
| CN-105793288-A | Anti-PDL1 antibody formulations | 豪夫迈·罗氏有限公司 | 2016-07-20 | — | — | CN | disclosed |
| CN-105744954-A | anti-RSPO 2 and/or anti-RSPO 3 antibodies and uses thereof | 豪夫迈·罗氏有限公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-103304667-A | Humanized anti-beta7 antagonists and uses therefor | GENENTECH INC | 2013-09-18 | — | — | CN | disclosed |
| CN-101094868-B | Humanized anti-beta 7 antagonists and uses thereof | GENENTECH INC | 2013-07-10 | — | — | CN | disclosed |