Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 3/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.77 |
| ▸ | POLA1 | P09884 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.41 |
| ▸ | ALB | P02768 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23258807 | 1.00 | PDE3A (0.77) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL18659340 | 0.91 | PDE3A (0.77) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL382458 | 0.90 | PDE3A (0.75) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL15788426 | 0.90 | PDE3A (0.75) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL19758224 | 0.90 | PDE3A (0.75) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL4750198 | 0.89 | PDE3A (0.73) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL15161127 | 0.89 | PDE3A (0.73) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL23171822 | 0.89 | PDE3A (0.73) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL10183126 | 0.89 | PDE3A (0.73) | PDE3APDE4DSLC29A1POLA1LMNA | |
| SCHEMBL24704190 | 0.88 | PDE3A (0.72) | PDE3APDE4DSLC29A1POLA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017053391-A1 | MODIFIED CYTOTOXINS AND THEIR THERAPEUTIC USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-30 | — | — | WO | disclosed |