Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21432437 | 0.74 | EPAS1 (0.33) | EPAS1 | |
| SCHEMBL18048416 | 0.69 | EPAS1 (0.49) | EPAS1 | |
| SCHEMBL21362881 | 0.66 | EPAS1 (0.40) | EPAS1 | |
| SCHEMBL25704500 | 0.65 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3RHEBLMNA | |
| SCHEMBL21362932 | 0.64 | EPAS1 (0.41) | EPAS1 | |
| SCHEMBL27777645 | 0.63 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3RHEBCYP3A4 | |
| SCHEMBL29543630 | 0.62 | POLB (0.56) | SLC6A2SLC6A4SLC6A3RHEBLMNA | |
| SCHEMBL2282611 | 0.62 | POLB (0.56) | SLC6A2SLC6A4SLC6A3RHEBLMNA | |
| SCHEMBL30688805 | 0.62 | POLB (0.56) | SLC6A2SLC6A4SLC6A3RHEBLMNA | |
| SCHEMBL10596007 | 0.60 | POLB (0.55) | SLC6A2SLC6A4SLC6A3RHEBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017053192-A1 | BIOMARKERS OF RESPONSE TO HIF-2-ALPHA INHIBITION IN CANCER AND METHODS FOR THE USE THEREOF | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-03-30 | — | — | WO | disclosed |