SCHEMBL1869256

SCHEMBL1869256

Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1CC1COC(C)(C(=O)NO)OC1

nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 12/20 0.50
PPARD Q03181 7/20 0.48
PPARA Q07869 7/20 0.48
PPARG P37231 5/20 0.48
NPC1 O15118 1/20 0.47
ALDH1A1 P00352 1/20 0.47
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12803179 0.85 PPARD (0.48) FFAR1PPARDPPARAPPARGNPC1
SCHEMBL1879205 0.83 PPARD (0.42) FFAR1PPARDPPARAPPARGNPC1
SCHEMBL1872847 0.83 PPARD (0.42) FFAR1PPARDPPARAPPARGNPC1
SCHEMBL4246080 0.80 PPARD (0.61) FFAR1PPARDPPARAPPARG
SCHEMBL4247774 0.80 PPARD (0.61) FFAR1PPARDPPARAPPARG
SCHEMBL4246297 0.79 PPARD (0.66) FFAR1PPARDPPARAPPARG
SCHEMBL4246301 0.79 PPARD (0.66) FFAR1PPARDPPARAPPARG
SCHEMBL4254697 0.79 PPARD (0.66) FFAR1PPARDPPARAPPARG
SCHEMBL1862898 0.78 FFAR1 (0.43) FFAR1PPARDPPARAPPARGNPC1
SCHEMBL11898272 0.78 PPARA (0.62) PPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483266-B1 COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES CADILA HEALTHCARE LTD (IN) 2015-02-25 EP claimed
EP-2567957-A1 Compounds for the treatment of dyslipidemia and related diseases CADILA HEALTHCARE LIMITED (IN) 2013-03-13 EP claimed
US-20120252796-A1 COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES CADILA HEALTHCARE LIMITED (IN) 2012-10-04 US claimed
EP-2483266-A1 COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES Cadila Healthcare Limited (IN) 2012-08-08 EP claimed
WO-2011051961-A1 COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES CADILA HEALTHCARE LIMITED (IN) 2011-05-05 WO claimed
EP-2483266-B1 COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES CADILA HEALTHCARE LTD (IN) 2015-02-25 EP disclosed
EP-2567957-A1 Compounds for the treatment of dyslipidemia and related diseases CADILA HEALTHCARE LIMITED (IN) 2013-03-13 EP disclosed
US-20120252796-A1 COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES CADILA HEALTHCARE LIMITED (IN) 2012-10-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120252796-A1 COMPOUNDS FOR THE TREATMENT OF DYSLIPIDEMIA AND RELATED DISEASES PCSK9, APOB, CPT1A FFAR1 160/4885PPARD 127/4885PPARA 132/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.