Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.63 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 4/20 | 0.56 |
| ▸ | CA1 | P00915 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | CA9 | Q16790 | 4/20 | 0.56 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.53 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.51 |
| ▸ | MAP1B | P46821 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20896874 | 0.93 | OPRM1 (0.61) | OPRM1SENP1CA12CA1CA2 | |
| SCHEMBL13735950 | 0.92 | OPRM1 (0.66) | OPRM1SENP1CA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL20896828 | 0.91 | OPRM1 (0.60) | OPRM1SENP1CA12CA1CA2 | |
| SCHEMBL22473633 | 0.89 | OPRM1 (0.64) | OPRM1SENP1CA12CA1CA2 | |
| SCHEMBL29427473 | 0.89 | OPRM1 (0.59) | OPRM1SENP1CA12CA1CA2 | |
| SCHEMBL25894852 | 0.88 | OPRM1 (0.58) | OPRM1SENP1CA12CA1CA2 | |
| SCHEMBL19134196 | 0.88 | OPRM1 (0.63) | OPRM1SENP1CA12CA1CA2 | |
| SCHEMBL20896592 | 0.88 | OPRM1 (0.61) | OPRM1SENP1CA12CA1CA2 | |
| SCHEMBL20896670 | 0.87 | CA12 (0.61) | OPRM1SENP1CA12CA1CA2 | |
| SCHEMBL20904552 | 0.87 | CA12 (0.61) | OPRM1SENP1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017527-B2 | KLK4 inhibitors | UNIVERSITEIT ANTWERPEN (BE) | 2018-07-10 | — | — | US | disclosed |
| US-20170101427-A1 | NOVEL KLK4 INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2017-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10017527-B2 | KLK4 inhibitors | KLK4, KLK3, KLK1 | OPRM1 1269/4885SENP1 2080/4885CA12 3969/4885 |
| US-20170101427-A1 | NOVEL KLK4 INHIBITORS | KLK4, KLK3, KLK1 | OPRM1 1325/4885SENP1 1989/4885CA12 4049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.