Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 14/20 | 0.72 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.66 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144777 | 1.00 | HCRTR1 (0.72) | HCRTR1HCRTR2MAP3K12OPRK1JAK2 | |
| SCHEMBL20145089 | 0.92 | HCRTR1 (0.62) | HCRTR1HCRTR2MAP3K12OPRK1JAK2 | |
| SCHEMBL20144963 | 0.92 | HCRTR1 (0.62) | HCRTR1HCRTR2MAP3K12OPRK1JAK2 | |
| SCHEMBL20144856 | 0.90 | HCRTR1 (0.66) | HCRTR1HCRTR2MAP3K12OPRK1JAK2 | |
| SCHEMBL20144938 | 0.90 | HCRTR1 (0.66) | HCRTR1HCRTR2MAP3K12OPRK1JAK2 | |
| SCHEMBL20144772 | 0.85 | HCRTR1 (0.70) | HCRTR1HCRTR2 | |
| SCHEMBL17506064 | 0.84 | HCRTR1 (1.00) | HCRTR1HCRTR2 | |
| SCHEMBL16031159 | 0.84 | HCRTR1 (1.00) | HCRTR1HCRTR2 | |
| SCHEMBL20144885 | 0.83 | HCRTR1 (0.69) | HCRTR1HCRTR2 | |
| SCHEMBL17510802 | 0.79 | HCRTR1 (1.00) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |
| US-9611251-B2 | Substituted piperidine compounds and their use as orexin receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-04 | — | — | US | disclosed |