Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 16/20 | 0.66 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.52 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20144938 | 1.00 | HCRTR1 (0.66) | HCRTR1HCRTR2MAP3K12JAK2JAK3 | |
| SCHEMBL18697646 | 0.90 | HCRTR1 (0.72) | HCRTR1HCRTR2MAP3K12JAK2JAK3 | |
| SCHEMBL20144777 | 0.90 | HCRTR1 (0.72) | HCRTR1HCRTR2MAP3K12JAK2JAK3 | |
| SCHEMBL1835677 | 0.83 | KDM4E (0.52) | HCRTR1HCRTR2MAP3K12LMNA | |
| SCHEMBL16030811 | 0.83 | HCRTR1 (0.82) | HCRTR1HCRTR2 | |
| SCHEMBL1141302 | 0.82 | MAP3K12 (0.51) | HCRTR1HCRTR2MAP3K12 | |
| SCHEMBL1141304 | 0.82 | MAP3K12 (0.51) | HCRTR1HCRTR2MAP3K12 | |
| SCHEMBL20145089 | 0.81 | HCRTR1 (0.62) | HCRTR1HCRTR2MAP3K12JAK2JAK3 | |
| SCHEMBL20144963 | 0.81 | HCRTR1 (0.62) | HCRTR1HCRTR2MAP3K12JAK2JAK3 | |
| SCHEMBL17028118 | 0.80 | HCRTR1 (1.00) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970207-B1 | SUBSTITUTED PIPERIDINE COMPOUNDS AND THEIR USE AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-16 | — | — | EP | disclosed |