Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 5/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15093794 | 0.86 | TLR4 (0.47) | TLR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1866347 | 0.86 | TLR4 (0.47) | TLR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1862851 | 0.86 | TLR4 (0.47) | TLR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4159467 | 0.85 | TLR4 (0.48) | TLR4PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1862994 | 0.83 | TLR4 (0.47) | TLR4KMT2AMRGPRX1 | |
| SCHEMBL1863031 | 0.83 | TLR4 (0.46) | TLR4NPC1RAB9AKMT2AMRGPRX1 | |
| SCHEMBL1864588 | 0.83 | TLR4 (0.46) | TLR4NPC1RAB9AKMT2AMRGPRX1 | |
| SCHEMBL1862043 | 0.81 | TLR4 (0.48) | TLR4KMT2AMRGPRX1 | |
| SCHEMBL1864173 | 0.80 | TLR4 (0.43) | TLR4MRGPRX1 | |
| SCHEMBL1864310 | 0.79 | TLR4 (0.61) | TLR4LMNAKMT2AMRGPRX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935835-B2 | Substituted cycloalkene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-05-03 | — | — | US | disclosed |