Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 19/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1866751 | 0.82 | PIK3CB (0.41) | PIK3CBPIK3CDPIK3CAPIK3CGGPR35 | |
| SCHEMBL1639041 | 0.81 | PIK3CB (0.51) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL12667018 | 0.77 | KDM4E (0.34) | — | |
| SCHEMBL23887170 | 0.75 | PIK3CA (0.41) | PIK3CAGPR35 | |
| SCHEMBL1869001 | 0.73 | PIK3CB (0.56) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL23887193 | 0.71 | CDK2 (0.41) | PIK3CA | |
| SCHEMBL23887339 | 0.68 | PIK3CA (0.49) | PIK3CBPIK3CA | |
| SCHEMBL23887146 | 0.67 | PIK3CA (0.43) | PIK3CA | |
| SCHEMBL1869107 | 0.66 | PIK3CB (0.60) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1875396 | 0.66 | PIK3CB (0.70) | PIK3CBPIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493870-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051704-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2011-05-05 | — | — | WO | disclosed |