Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 15/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870074 | 0.82 | PIK3CB (0.39) | PIK3CBPIK3CDPIK3CAPIK3CGGPR35 | |
| SCHEMBL1639065 | 0.80 | PIK3CB (0.52) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL1637326 | 0.75 | CSNK2A2 (0.37) | KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL1869001 | 0.75 | PIK3CB (0.56) | PIK3CBPIK3CDPIK3CAPIK3CG | |
| SCHEMBL24713822 | 0.74 | KDM4E (0.35) | KDM4EALDH1A1TSHRHSD17B10GPR35 | |
| SCHEMBL23886985 | 0.74 | PIK3CA (0.40) | PIK3CAALDH1A1HSD17B10GPR35 | |
| SCHEMBL23886970 | 0.74 | CCNE2 (0.35) | GPR35 | |
| SCHEMBL23887223 | 0.74 | KDM4E (0.42) | PIK3CAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL24713633 | 0.73 | TNKS (0.36) | PIK3CBPIK3CDPIK3CAPIK3CGKDM4E | |
| SCHEMBL24714348 | 0.73 | KDM4E (0.35) | PIK3CBPIK3CDPIK3CAPIK3CGKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493870-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | AstraZeneca AB (SE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011051704-A1 | CHROMENONE DERIVATIVES WITH ANTI-TUMOUR ACTIVITY | ASTRAZENECA AB (SE) | 2011-05-05 | — | — | WO | disclosed |