Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868311 | 0.91 | ADORA1 (0.34) | ADORA3ADORA1ADORA2AKMT2AADORA2B | |
| SCHEMBL1866092 | 0.89 | PDE5A (0.33) | KMT2APKMMAOAMAOBGRM5 | |
| SCHEMBL1871420 | 0.82 | ADORA1 (0.41) | ADORA3ADORA1ADORA2AKMT2AADORA2B | |
| SCHEMBL1866236 | 0.82 | ADORA1 (0.41) | ADORA3ADORA1ADORA2AKMT2AADORA2B | |
| SCHEMBL1875007 | 0.80 | ADORA1 (0.55) | ADORA3ADORA1ADORA2AADORA2BKDM2B | |
| SCHEMBL1868543 | 0.80 | ADORA1 (0.35) | ADORA3ADORA1ADORA2AKMT2AADORA2B | |
| SCHEMBL1871164 | 0.80 | ADORA1 (0.45) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL1866939 | 0.80 | ADORA1 (0.44) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL1870705 | 0.79 | ADORA1 (0.42) | ADORA3ADORA1ADORA2AADORA2B | |
| SCHEMBL1869240 | 0.79 | ADORA1 (0.38) | ADORA3ADORA1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499142-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | Advinus Therapeutics Limited (IN) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011055391-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-05-12 | — | — | WO | disclosed |