Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 9/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1867015 | 0.82 | ADORA1 (0.47) | ADORA1ADORA2BADORA2AMEN1GMNN | |
| SCHEMBL1870248 | 0.80 | ADORA3 (0.39) | ADORA1ADORA2BADORA2AADORA3KMT2A | |
| SCHEMBL1871420 | 0.80 | ADORA1 (0.41) | ADORA1ADORA2BADORA2AMEN1GMNN | |
| SCHEMBL1868311 | 0.79 | ADORA1 (0.34) | ADORA1ADORA2BADORA2AMEN1GMNN | |
| SCHEMBL1871069 | 0.79 | ADORA1 (0.54) | ADORA1ADORA2BADORA2AMEN1GMNN | |
| SCHEMBL1870822 | 0.78 | ADORA1 (0.55) | ADORA1ADORA2BADORA2AMEN1GMNN | |
| SCHEMBL1870309 | 0.78 | ADORA1 (0.55) | ADORA1ADORA2BADORA2AMEN1GMNN | |
| SCHEMBL1887812 | 0.78 | ADORA2B (0.39) | ADORA1ADORA2BADORA2AMEN1GMNN | |
| SCHEMBL1869565 | 0.77 | ADORA2A (0.40) | ADORA1ADORA2BADORA2AMEN1GMNN | |
| SCHEMBL1864786 | 0.77 | ADORA1 (0.39) | ADORA1ADORA2BADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499142-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | Advinus Therapeutics Limited (IN) | 2012-09-19 | — | — | EP | claimed |
| WO-2011055391-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-05-12 | — | — | WO | claimed |