Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 14/20 | 0.67 |
| ▸ | KDM5C | P41229 | 8/20 | 0.67 |
| ▸ | KDM5A | P29375 | 7/20 | 0.67 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.67 |
| ▸ | KDM4A | O75164 | 2/20 | 0.56 |
| ▸ | KDM6B | O15054 | 1/20 | 0.56 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.56 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.56 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291798 | 0.91 | KDM5B (0.81) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL18286846 | 0.84 | KDM5B (0.80) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL18708312 | 0.83 | KDM5B (0.80) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19676454 | 0.81 | KDM5B (0.61) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16912742 | 0.81 | KDM5B (0.56) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL16912741 | 0.81 | KDM5B (0.56) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL18708207 | 0.81 | KDM5B (0.58) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL19676423 | 0.81 | KDM5B (0.54) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL15637431 | 0.80 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4CKDM4A | |
| SCHEMBL29373338 | 0.80 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |