Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 11/20 | 0.40 |
| ▸ | KDM5C | P41229 | 8/20 | 0.40 |
| ▸ | KDM5A | P29375 | 7/20 | 0.40 |
| ▸ | KDM4A | O75164 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18699881 | 0.80 | KDM5B (0.37) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16292979 | 0.78 | CHRM2 (0.41) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291684 | 0.78 | KDM5B (0.64) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16305488 | 0.77 | CHRM2 (0.43) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16292333 | 0.77 | KDM5B (0.40) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15994303 | 0.77 | TERT (0.38) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16293382 | 0.76 | CHRM2 (0.42) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16293260 | 0.75 | CHRM2 (0.71) | CHRM2SIRT2TERTALOX15 | |
| SCHEMBL16305525 | 0.74 | TERT (0.44) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291904 | 0.74 | KDM5B (0.65) | KDM5BKDM5CKDM5AKDM4AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |