Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 17/20 | 0.72 |
| ▸ | KDM5C | P41229 | 11/20 | 0.72 |
| ▸ | KDM5A | P29375 | 8/20 | 0.72 |
| ▸ | KDM4A | O75164 | 4/20 | 0.72 |
| ▸ | KDM6B | O15054 | 1/20 | 0.72 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.72 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.59 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.59 |
| ▸ | KDM4B | O94953 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15635961 | 0.93 | KDM5B (0.65) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL17772476 | 0.92 | KDM5B (0.69) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL18708603 | 0.85 | KDM5B (0.55) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636679 | 0.84 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15637033 | 0.81 | KDM5B (0.77) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16310777 | 0.79 | KDM5B (0.67) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL18708312 | 0.78 | KDM5B (0.80) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL19676491 | 0.76 | KDM5B (0.67) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636266 | 0.75 | KDM5B (0.74) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16293466 | 0.75 | KDM5B (0.59) | KDM5BKDM5CKDM5AKDM4AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |