Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 16/20 | 0.55 |
| ▸ | KDM5C | P41229 | 10/20 | 0.55 |
| ▸ | KDM5A | P29375 | 7/20 | 0.55 |
| ▸ | KDM4A | O75164 | 4/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.55 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.51 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.51 |
| ▸ | KDM4B | O94953 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15635961 | 0.92 | KDM5B (0.65) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL18708428 | 0.85 | KDM5B (0.72) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL17772476 | 0.84 | KDM5B (0.69) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL19676491 | 0.74 | KDM5B (0.67) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636679 | 0.71 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16293466 | 0.68 | KDM5B (0.59) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15637033 | 0.68 | KDM5B (0.77) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL25380189 | 0.68 | KDM5B (1.00) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL14423157 | 0.67 | ALDH1A1 (0.58) | SMN1; SMN2MAPTALDH1A1LMNAHPGD | |
| SCHEMBL29129147 | 0.67 | KDM5B (0.60) | KDM5BKDM5CKDM5AKDM4AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |