Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15161493 | 0.67 | TDP1 (0.42) | TDP1ACHENISCHKDM4ENPC1 | |
| SCHEMBL14551129 | 0.65 | TDP1 (0.35) | TDP1ACHENISCHKDM4ENPC1 | |
| SCHEMBL11185800 | 0.64 | ACHE (0.44) | TDP1ACHENISCHKDM4ENPC1 | |
| SCHEMBL18661495 | 0.63 | ACHE (0.73) | TDP1ACHEHPGDALDH1A1HSD17B10 | |
| SCHEMBL197731 | 0.63 | ACHE (0.73) | TDP1ACHEHPGDALDH1A1HSD17B10 | |
| SCHEMBL3287696 | 0.63 | ACHE (0.73) | TDP1ACHEHPGDALDH1A1HSD17B10 | |
| SCHEMBL19100322 | 0.62 | TDP1 (0.36) | TDP1ACHENISCHKDM4ENPC1 | |
| SCHEMBL22049777 | 0.61 | NISCH (0.35) | NISCHKDM4ERAB9AHPGDALDH1A1 | |
| SCHEMBL25304741 | 0.61 | HPGD (0.38) | TDP1ACHEKDM4ENPC1RAB9A | |
| Water SCHEMBL3763584 | 0.60 | ACHE (0.67) | TDP1ACHEHPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611230-B2 | 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease | PTC THERAPEUTICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |