Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 8/20 | 0.52 |
| ▸ | RAB9A | P51151 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.50 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | STIM1 | Q13586 | 5/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.42 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708494 | 0.89 | NPC1 (0.61) | MYCNPC1RAB9AKMT2AKDM5A | |
| SCHEMBL12798145 | 0.83 | MYC (0.57) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12171594 | 0.82 | MYC (0.52) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL12171364 | 0.80 | NPC1 (0.73) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL4395868 | 0.80 | NPC1 (0.72) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL11579267 | 0.80 | NPC1 (0.66) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1675428 | 0.80 | TTR (0.47) | NPC1RAB9AKDM5AKDM2BKDM4C | |
| SCHEMBL12171784 | 0.79 | NPC1 (0.62) | MYCNPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL10194338 | 0.79 | KDM5A (0.53) | KDM5AKDM2BKDM4CKDM5BALDH1A1 | |
| SCHEMBL12171906 | 0.78 | NPC1 (0.62) | MYCNPC1RAB9AKMT2AKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611230-B2 | 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease | PTC THERAPEUTICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |