Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708489 | 0.89 | MYC (0.53) | NPC1RAB9AKMT2AMGLLKDM5A | |
| SCHEMBL321724 | 0.85 | LMNA (0.61) | LMNAMGLLKDM5AKDM2BKDM4C | |
| SCHEMBL1675470 | 0.79 | HDAC6 (0.51) | KDM5AKDM2BKDM4CKDM5BHDAC6 | |
| SCHEMBL11438341 | 0.79 | NPC1 (0.89) | NPC1RAB9AKMT2AMYCHDAC6 | |
| SCHEMBL12171532 | 0.78 | RAB9A (0.57) | NPC1RAB9AKMT2AMYCHDAC6 | |
| SCHEMBL4883318 | 0.77 | NPC1 (1.00) | NPC1RAB9AKMT2AMYCHDAC6 | |
| SCHEMBL12171414 | 0.76 | NPC1 (0.96) | NPC1RAB9AKMT2AMYCHDAC6 | |
| SCHEMBL12170932 | 0.75 | NPC1 (0.74) | NPC1RAB9AKMT2AMYCHDAC6 | |
| SCHEMBL17303476 | 0.74 | NOTUM (0.58) | KMT2ALMNAMGLLKDM4EALDH1A1 | |
| SCHEMBL2401139 | 0.73 | NOTUM (0.53) | NPC1RAB9AKMT2ALMNAMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611230-B2 | 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease | PTC THERAPEUTICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |