Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 17/20 | 0.55 |
| ▸ | KDM5C | P41229 | 9/20 | 0.55 |
| ▸ | KDM5A | P29375 | 9/20 | 0.55 |
| ▸ | KDM4A | O75164 | 4/20 | 0.55 |
| ▸ | KDM6B | O15054 | 1/20 | 0.55 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.55 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.43 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.43 |
| ▸ | KDM4B | O94953 | 2/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708386 | 0.80 | KDM5B (0.47) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291579 | 0.80 | KDM5B (0.62) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16912746 | 0.79 | KDM5B (0.48) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291896 | 0.79 | KDM5B (0.57) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16292445 | 0.77 | KDM5B (0.49) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291504 | 0.76 | KDM5B (0.46) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291806 | 0.75 | KDM5B (0.53) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636266 | 0.73 | KDM5B (0.74) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15636442 | 0.72 | KDM5B (0.52) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291759 | 0.71 | KDM5B (0.49) | KDM5BKDM5CKDM5AKDM4AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |