Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 11/20 | 0.47 |
| ▸ | KDM5C | P41229 | 6/20 | 0.47 |
| ▸ | KDM5A | P29375 | 6/20 | 0.47 |
| ▸ | KDM4A | O75164 | 4/20 | 0.47 |
| ▸ | KDM6B | O15054 | 3/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.40 |
| ▸ | KDM4B | O94953 | 1/20 | 0.40 |
| ▸ | TET3 | O43151 | 1/20 | 0.40 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708385 | 0.82 | KDM5B (0.46) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL18708529 | 0.80 | KDM5B (0.55) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291489 | 0.78 | KDM5C (0.41) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL17144520 | 0.78 | TRPV3 (0.50) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL17144518 | 0.78 | TRPV3 (0.50) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL15987656 | 0.76 | KDM5B (0.56) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL19549130 | 0.75 | KDM5B (0.47) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16055756 | 0.74 | KDM4E (0.65) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL1647272 | 0.73 | CYP1A2 (0.61) | KDM5BKDM5CKDM5AKDM4AKDM6B | |
| SCHEMBL16291806 | 0.73 | KDM5B (0.53) | KDM5BKDM5CKDM5AKDM4AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3023415-B1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES INC (US) | 2017-12-06 | — | — | EP | disclosed |
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |