Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20296959 | 1.00 | LMNA (0.67) | LMNAHPGDHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL18687092 | 0.85 | LMNA (0.48) | LMNAHPGDHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL18709362 | 0.85 | LMNA (0.48) | LMNAHPGDHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL20296955 | 0.85 | DDIT3 (0.61) | MAPTKMT2ARAB9ANPC1 | |
| SCHEMBL18709397 | 0.85 | DDIT3 (0.61) | MAPTKMT2ARAB9ANPC1 | |
| SCHEMBL17329224 | 0.83 | MEN1 (0.47) | LMNAHPGDHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL17329223 | 0.83 | MEN1 (0.47) | LMNAHPGDHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL18687078 | 0.82 | LMNA (0.66) | LMNAHPGDALDH1A1SMN1; SMN2HTT | |
| SCHEMBL18687079 | 0.82 | LMNA (0.66) | LMNAHPGDALDH1A1SMN1; SMN2HTT | |
| SCHEMBL17329183 | 0.80 | PRMT1 (0.52) | LMNAHPGDALDH1A1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10071994-B2 | N-sulfonyl homoserine lactone derivatives, preparation method and use thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-09-11 | — | — | US | claimed |
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-06-28 | — | — | US | claimed |
| US-10071994-B2 | N-sulfonyl homoserine lactone derivatives, preparation method and use thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-09-11 | — | — | US | disclosed |
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-06-28 | — | — | US | disclosed |
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-06-28 | — | — | US | disclosed |
| EP-3150594-A1 | N-SULFONYL HOMOSERINE LACTONE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2017-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179193-A1 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | LSS, SOS1, STS | LMNA 1575/4885HPGD 640/4885HSD17B10 688/4885 |
| US-10071994-B2 | N-sulfonyl homoserine lactone derivatives, preparation method and use thereof | LSS, SOS1, STS | LMNA 1447/4885HPGD 685/4885HSD17B10 621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.