Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1871283 | 0.88 | RIPK2 (0.40) | BRAFRIPK2KCNH2EGFRAR | |
| SCHEMBL1871377 | 0.85 | BRAF (0.41) | BRAFRIPK2KCNH2EGFRAR | |
| SCHEMBL1872504 | 0.85 | BRAF (0.42) | BRAFRIPK2KCNH2EGFRAR | |
| SCHEMBL1871101 | 0.82 | BRAF (0.40) | BRAFRIPK2KCNH2EGFRAR | |
| SCHEMBL1127145 | 0.81 | KCNH2 (0.44) | BRAFRIPK2KCNH2EGFRAR | |
| SCHEMBL1874683 | 0.80 | RIPK2 (0.38) | BRAFRIPK2KCNH2EGFRAR | |
| SCHEMBL12237762 | 0.79 | BRAF (0.46) | BRAFRIPK2KCNH2EGFRNR1I2 | |
| SCHEMBL1871408 | 0.78 | RIPK2 (0.37) | BRAFRIPK2KCNH2EGFRAR | |
| SCHEMBL2193376 | 0.78 | BRAF (0.47) | BRAFRIPK2KCNH2EGFRNR1I2 | |
| SCHEMBL2194702 | 0.77 | BRAF (0.46) | BRAFRIPK2KCNH2EGFRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |