Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.43 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.43 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.43 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64439 | 0.88 | FGFR1 (0.51) | FGFR2FGFR1AURKBNTRK1RET | |
| SCHEMBL4438354 | 0.78 | FGFR3 (0.38) | FGFR2FGFR1AURKBNTRK1RET | |
| SCHEMBL63441 | 0.76 | FGFR1 (0.52) | FGFR1AURKBNTRK1RETPDGFRB | |
| SCHEMBL65154 | 0.75 | FGFR1 (0.50) | FGFR2FGFR1AURKBNTRK1RET | |
| SCHEMBL63601 | 0.75 | FGFR1 (0.50) | FGFR2FGFR1AURKBNTRK1RET | |
| SCHEMBL29688533 | 0.74 | FGFR1 (0.54) | FGFR2FGFR1AURKBNTRK1RET | |
| SCHEMBL64111 | 0.74 | FGFR1 (0.56) | FGFR2FGFR1AURKBNTRK1RET | |
| SCHEMBL64062 | 0.74 | FGFR1 (0.55) | FGFR2FGFR1AURKBNTRK1RET | |
| SCHEMBL63681 | 0.74 | FGFR2 (0.45) | FGFR2FGFR1AURKBNTRK1RET | |
| SCHEMBL65013 | 0.73 | FGFR1 (0.54) | FGFR2FGFR1AURKBNTRK1RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-B1 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2011-05-25 | — | — | EP | disclosed |