Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 12/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | PDE8A | O60658 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16981636 | 0.81 | PDE9A (0.77) | PDE9AKDM4EALDH1A1PDE5APDE1B | |
| SCHEMBL18712798 | 0.79 | LMNA (0.53) | KDM4ESMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL26010870 | 0.78 | PDE9A (0.40) | PDE9AKDM4EALDH1A1 | |
| SCHEMBL16981664 | 0.78 | PDE9A (1.00) | PDE9A | |
| SCHEMBL18712795 | 0.77 | PDE9A (0.63) | PDE9ASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL26010871 | 0.77 | PDE9A (0.38) | PDE9AKDM4EALDH1A1PDE2A | |
| SCHEMBL16981731 | 0.75 | PDE9A (1.00) | PDE9A | |
| SCHEMBL16981691 | 0.74 | PDE9A (1.00) | PDE9APDE5APDE1BPDE2APDE8A | |
| SCHEMBL16981715 | 0.73 | PDE9A (1.00) | PDE9APDE5APDE1BPDE2APDE8A | |
| SCHEMBL15693168 | 0.72 | TNKS (0.55) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617269-B2 | N-substituted pyrazolo [3,4-D] pyrimidine ketone compound, and preparation process and use thereof | SUN YAT-SEN UNIVERSITY (CN) | 2017-04-11 | — | — | US | disclosed |