Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18714754 | 0.82 | HIF1A (0.53) | POLBHIF1ASIGMAR1TMEM97NSD2 | |
| SCHEMBL18714870 | 0.80 | HIF1A (0.55) | HIF1ALMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL18714847 | 0.80 | HIF1A (0.52) | HIF1ASIGMAR1TMEM97LMNAALDH1A1 | |
| SCHEMBL14183081 | 0.75 | POLB (0.59) | POLBSIGMAR1TMEM97NSD2LMNA | |
| SCHEMBL18714781 | 0.75 | TMEM97 (0.53) | HIF1ASIGMAR1TMEM97LMNALTA4H | |
| SCHEMBL6125252 | 0.75 | SIGMAR1 (0.52) | POLBHIF1ASIGMAR1TMEM97NSD2 | |
| SCHEMBL4664138 | 0.73 | HRH3 (0.55) | POLBHIF1ASIGMAR1TMEM97NSD2 | |
| SCHEMBL18295341 | 0.73 | MAPK8 (0.55) | LMNARORCHTTMAPK8 | |
| SCHEMBL18714871 | 0.72 | SIGMAR1 (0.56) | POLBSIGMAR1TMEM97NSD2 | |
| SCHEMBL17372411 | 0.72 | SIGMAR1 (0.62) | POLBHIF1ASIGMAR1TMEM97RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150576-B1 | SUBSTITUTED ACETOHYDRAZIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2019-07-10 | — | — | EP | disclosed |
| US-10196346-B2 | Substituted acethydrazide derivative, preparation method and use thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2019-02-05 | — | — | US | disclosed |
| US-20180134653-A1 | SUBSTITUTED ACETHYDRAZIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-05-17 | — | — | US | disclosed |
| US-20180134653-A1 | SUBSTITUTED ACETHYDRAZIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-05-17 | — | — | US | disclosed |
| US-20170190656-A1 | A Substituted Acethydrazide Derivative, Preparation Method and Use Thereof | Institute of Pharmacology and Toxicology Academy of Millitary Medical Sciences P.L.A. China (CN) | 2017-07-06 | — | — | US | disclosed |
| US-20170190656-A1 | A Substituted Acethydrazide Derivative, Preparation Method and Use Thereof | Institute of Pharmacology and Toxicology Academy of Millitary Medical Sciences P.L.A. China (CN) | 2017-07-06 | — | — | US | disclosed |
| EP-3150576-A1 | SUBSTITUTED ACETOHYDRAZIDE DERIVATIVES, PREPARATION METHOD THEREFOR AND USE | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2017-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190656-A1 | A Substituted Acethydrazide Derivative, Preparation Method and Use Thereof | HIF1AN, HIF1A, EGLN3 | POLB 2841/4885HIF1A 2/4885SIGMAR1 1828/4885 |
| US-20180134653-A1 | SUBSTITUTED ACETHYDRAZIDE DERIVATIVE, PREPARATION METHOD AND USE THEREOF | HIF1AN, HIF1A, EGLN3 | POLB 2896/4885HIF1A 2/4885SIGMAR1 1851/4885 |
| US-10196346-B2 | Substituted acethydrazide derivative, preparation method and use thereof | HIF1AN, HIF1A, EGLN3 | POLB 2896/4885HIF1A 2/4885SIGMAR1 1851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.