SCHEMBL187151

SCHEMBL187151

COc1c(O)ccc(/C=C/C(=O)O)c1OC

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.51
CA1 P00915 3/20 0.51
CA2 P00918 3/20 0.51
CA4 P22748 3/20 0.51
PKM P14618 2/20 0.51
CA12 O43570 2/20 0.51
CA3 P07451 2/20 0.51
CA6 P23280 2/20 0.51
CA5A P35218 2/20 0.51
CA7 P43166 2/20 0.51
CA9 Q16790 2/20 0.51
CA14 Q9ULX7 2/20 0.51
CA5B Q9Y2D0 2/20 0.51
CSNK2A2 P19784 1/20 0.51
SNCA P37840 1/20 0.51
CSNK2B P67870 1/20 0.51
CSNK2A1 P68400 1/20 0.51
CSNK2A3 Q8NEV1 1/20 0.51
ABCG2 Q9UNQ0 1/20 0.50
NFKB1 P19838 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL187153 1.00 KDM4E (0.51) KDM4ECA1CA2CA4PKM
SCHEMBL6852627 0.91 ABCG2 (0.57) KDM4ECA1CA2CA4PKM
SCHEMBL6852630 0.91 ABCG2 (0.57) KDM4ECA1CA2CA4PKM
SCHEMBL21317660 0.88 KDM4E (0.50) KDM4ECA1CA2CA4PKM
SCHEMBL6655468 0.88 KDM4E (0.50) KDM4ECA1CA2CA4PKM
SCHEMBL21317659 0.88 KDM4E (0.50) KDM4ECA1CA2CA4PKM
SCHEMBL2535572 0.87 KDM4E (0.49) KDM4ECA1CA2CA4PKM
SCHEMBL10875625 0.87 KDM4E (0.49) KDM4ECA1CA2CA4PKM
SCHEMBL10445525 0.85 CA1 (0.62) KDM4ECA1CA2CA4PKM
SCHEMBL10445523 0.85 CA1 (0.62) KDM4ECA1CA2CA4PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8653326-B2 Targeted DNA insertion in plants BAYER CROPSCIENCE N.V. (BE) 2014-02-18 US claimed
US-20100003759-A1 TARGETED DNA INSERTION IN PLANTS BAYER BIOSCIENCE N.V. (BE) 2010-01-07 US claimed
US-7598365-B2 Targeted DNA insertion in plants BAYER BIOSCIENCE N.V. (BE) 2009-10-06 US claimed
EP-1689870-A2 IMPROVED TARGETED DNA INSERTION IN PLANTS Bayer BioScience N.V. (BE) 2006-08-16 EP claimed
WO-2005049842-A2 IMPROVED TARGETED DNA INSERTION IN PLANTS BAYER BIOSCIENCE N.V. (BE) 2005-06-02 WO claimed
US-11746364-B2 Enzymatic synthesis of kavalactones and flavokavains WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2023-09-05 US disclosed
US-11739354-B2 Enzymatic synthesis of kavalactones and flavokavains WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2023-08-29 US disclosed
US-20220002768-A1 ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2022-01-06 US disclosed
US-20220002769-A1 ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2022-01-06 US disclosed
US-10941429-B2 Enzymatic synthesis of kavalactones and flavokavains WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2021-03-09 US disclosed
US-10570402-B2 Agrobacterium strains for plant transformation TEMASEK LIFE SCIENCES LABORATORY LIMITED (SG) 2020-02-25 US disclosed
US-20190271015-A1 ENZYMATIC SYNTHESIS OF KAVALACTONES AND FLAVOKAVAINS WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH 2019-09-05 US disclosed
EP-0782581-A4 CLONING OF AN INSULIN-DEPENDENT MEMBRANE AMINOPEPTIDASE FROM GLUT-4 VESICLES BAYER AG (US) 2000-05-31 EP disclosed
WO-2000026348-A2 MAMMALIAN SUBTILISIN/KEXIN ISOZYME SKI-1: A PROPROTEIN CONVERTASE WITH A UNIQUE CLEAVAGE SPECIFICITY INSTITUT DE RECHERCHES CLINIQUES DE MONTREAL (CA) 2000-05-11 WO disclosed
US-5972680-A AN AMINOPEPTIDASE WHICH IS INVOLVED IN INSULIN REGULATION. BAYER CORPORATION (US) 1999-10-26 US disclosed
US-5968764-A DETECTING MODULATORS OF GLUCOSE TRANSPORT PROTEIN; THERAPY FOR DIABETES AND DISORDERS OF INSULIN RESISTANCE, BY INCUBATING GLUCOSE TRANSPORT PROTEIN WITH TEST COMPOUND, ADDING TRANSPORT PROTEIN SUBSTRATE, MONITORING EFFECT BAYER CORPORATION (US) 1999-10-19 US disclosed
EP-0900279-A1 IMPROVED TRANSFORMATION METHOD FOR PLANTS PLANT GENETIC SYSTEMS N.V. (BE) 1999-03-10 EP disclosed
WO-1998037212-A1 IMPROVED TRANSFORMATION METHOD FOR PLANTS PLANT GENETIC SYSTEMS, N.V. (BE) 1998-08-27 WO disclosed
EP-0782581-A1 CLONING OF AN INSULIN-DEPENDENT MEMBRANE AMINOPEPTIDASE FROM GLUT-4 VESICLES Bayer Corporation (US) 1997-07-09 EP disclosed
WO-1996009317-A1 CLONING OF AN INSULIN-DEPENDENT MEMBRANE AMINOPEPTIDASE FROM GLUT-4 VESICLES BAYER CORPORATION (US) 1996-03-28 WO disclosed