SCHEMBL18716997

CC(=O)NCCC[C@@H]1NC(=O)C(NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)CCC(=O)NCCCC(C(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)C(Cc2ccccc2)NC1=O

nearest known ligand 0.53

Predicted protein targets (top 11)

	gene	UniProt	supporting neighbours	confidence
▸	MC4R	P32245	9/20	0.53

▸	FURIN	P09958	1/20	0.51

▸	FCGRT	P55899	1/20	0.46

▸	MC5R	P33032	2/20	0.46

▸	MC3R	P41968	2/20	0.46

▸	MC1R	Q01726	2/20	0.46

▸	PLK1	P53350	1/20	0.45

▸	KEAP1	Q14145	1/20	0.45

▸	SIRT2	Q8IXJ6	1/20	0.45

▸	SIRT1	Q96EB6	1/20	0.45

▸	SIRT3	Q9NTG7	1/20	0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20642726	0.96	MC4R (0.54)	MC4RFURINFCGRTMC5RMC3R
SCHEMBL18716979	0.94	MC4R (0.59)	MC4RFURINFCGRTMC5RMC3R
SCHEMBL18716994	0.92	MC4R (0.53)	MC4RFURINFCGRTMC5RMC3R
SCHEMBL20642818	0.91	MC4R (0.59)	MC4RFURINFCGRTMC5RMC3R
SCHEMBL20642717	0.90	FCGRT (0.52)	MC4RFURINFCGRTMC5RMC3R
SCHEMBL20642765	0.90	MC4R (0.50)	MC4RFURINKEAP1
SCHEMBL19473946	0.90	MC4R (0.53)	MC4RFURINFCGRTKEAP1
SCHEMBL19473950	0.90	MC4R (0.61)	MC4RFURINMC5RMC3RMC1R
SCHEMBL19473857	0.89	MC4R (0.58)	MC4RFURINMC5RMC3RMC1R
SCHEMBL19474002	0.89	SIRT2 (0.48)	MC4RFURINMC3RSIRT2SIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2440572-B1	LACTAM-BRIDGED MELANOCORTIN RECEPTOR-SPECIFIC PEPTIDES	PALATIN TECHNOLOGIES INC (US)	2017-04-05	—	—	EP	disclosed