Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 6/20 | 0.35 |
| ▸ | MRGPRX1 | Q96LB2 | 5/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1876513 | 0.91 | BRAF (0.39) | PTGS1PTGS2BRAFMRGPRX1GLO1 | |
| SCHEMBL1882268 | 0.87 | BRAF (0.41) | PTGS1PTGS2BRAF | |
| SCHEMBL1879184 | 0.80 | PTGS1 (0.36) | PTGS1PTGS2BRAFMRGPRX1GLO1 | |
| SCHEMBL1873673 | 0.79 | BRAF (0.49) | BRAF | |
| SCHEMBL3882959 | 0.77 | GAA (0.37) | TRPV1 | |
| SCHEMBL1874818 | 0.74 | PDK2 (0.52) | PTGS1PTGS2MRGPRX1 | |
| SCHEMBL24761235 | 0.73 | ERCC5 (0.47) | — | |
| SCHEMBL29751913 | 0.73 | ERCC5 (0.47) | — | |
| SCHEMBL31264106 | 0.73 | SLC40A1 (0.39) | PTGS2BRAFTRPV1ERN1SLC40A1 | |
| SCHEMBL30605882 | 0.73 | SLC40A1 (0.39) | PTGS2TRPV1SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |