Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1870444 | 0.93 | BRAF (0.44) | BRAF | |
| SCHEMBL1875723 | 0.93 | BRAF (0.41) | BRAF | |
| SCHEMBL1872256 | 0.89 | BRAF (0.40) | BRAF | |
| SCHEMBL1866858 | 0.89 | BRAF (0.46) | BRAFLMNAMAPTMMP13 | |
| SCHEMBL1870874 | 0.86 | BRAF (0.38) | BRAF | |
| SCHEMBL12669624 | 0.86 | BRAF (0.40) | BRAF | |
| SCHEMBL1868804 | 0.83 | RIPK2 (0.41) | BRAF | |
| SCHEMBL1870511 | 0.83 | BRAF (0.45) | BRAF | |
| SCHEMBL1127020 | 0.83 | BRAF (0.49) | BRAF | |
| SCHEMBL1875721 | 0.82 | BRAF (0.42) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |