Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.36 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | TERT | O14746 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1874422 | 0.92 | PDE10A (0.37) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL1873473 | 0.89 | NPC1 (0.37) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL2321107 | 0.87 | ERN1 (0.39) | MEN1KMT2ACYP1A2PIK3CA | |
| SCHEMBL12394014 | 0.85 | MEN1 (0.49) | MAPTMEN1KMT2APDE10APDE2A | |
| SCHEMBL2318886 | 0.83 | PIK3CD (0.34) | PDE10APDE2AGRM8CYP1A2GRM7 | |
| SCHEMBL3331310 | 0.78 | RAC1 (0.39) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2319119 | 0.77 | GRM8 (0.33) | MEN1KMT2APDE10APDE2AGRM8 | |
| SCHEMBL13165379 | 0.77 | MEN1 (0.47) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL3616326 | 0.76 | MEN1 (0.36) | NPC1MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL121151 | 0.76 | PIK3CD (0.34) | NPC1RAB9AMEN1KMT2APDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410026-B2 | Pyridazine fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-04-02 | — | — | US | claimed |
| US-20110112108-A1 | PYRIDAZINE FUNGICIDES | SYNGENTA CROP PROTECTION AG (US) | 2011-05-12 | — | — | US | claimed |
| EP-2231637-A1 | PYRIDAZINE FUNGICIDES | Syngenta Participations AG (CH) | 2010-09-29 | — | — | EP | claimed |
| WO-2009090039-A1 | PYRIDAZINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-07-23 | — | — | WO | claimed |
| US-8410026-B2 | Pyridazine fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-04-02 | — | — | US | disclosed |
| EP-2231637-B1 | PYRIDAZINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-12-19 | — | — | EP | disclosed |
| US-20110112108-A1 | PYRIDAZINE FUNGICIDES | SYNGENTA CROP PROTECTION AG (US) | 2011-05-12 | — | — | US | disclosed |
| EP-2231637-A1 | PYRIDAZINE FUNGICIDES | Syngenta Participations AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009090039-A1 | PYRIDAZINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112108-A1 | PYRIDAZINE FUNGICIDES | CBR3, CBR1, CYP4Z1 | NPC1 2751/4885MAPT 4626/4885RAB9A 1740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.