Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18723257 | 0.80 | ACHE (0.57) | HPGDTLR7HDAC1POLBRAB9A | |
| SCHEMBL14368136 | 0.73 | HPGD (0.51) | HPGDTLR7HDAC1TDP1RAB9A | |
| Hydrochloric Acid SCHEMBL2078038 | 0.69 | CHEK1 (0.54) | CHEK1 | |
| SCHEMBL1759068 | 0.67 | KDM4D (0.57) | MAPT | |
| SCHEMBL28477473 | 0.65 | MEN1 (0.60) | HDAC1POLBGAANPC1MAPT | |
| Hydrochloric Acid SCHEMBL16446715 | 0.65 | KDM4D (0.55) | MAPT | |
| SCHEMBL2213755 | 0.65 | KDM5A (0.62) | LMNAHPGDPOLBGAANPC1 | |
| SCHEMBL10054633 | 0.65 | TLR7 (0.47) | LMNAHPGDTLR7TDP1IRAK4 | |
| SCHEMBL28478726 | 0.64 | MEN1 (0.58) | HDAC1POLBGAANPC1MAPT | |
| SCHEMBL12704788 | 0.64 | NPC1 (0.77) | HDAC1TDP1RAB9AGAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617282-B2 | Macrocyclic compounds as IRAK4 inhibitors for the treatment of inflammatory diseases | BIOGEN MA INC. (US) | 2017-04-11 | — | — | US | disclosed |